Impact of Personalised Cardiac Anaesthesia and Cerebral Autoregulation on Neurological Outcomes in Patients Undergoing Cardiac Surgery

Recruiting now

Conditions studied: Postoperative Delirium, Postoperative Stroke, Postoperative Cognitive Dysfunction

In brief

This international, multicentre prospective cohort study will assess whether perioperative duration and magnitude of mean arterial pressure (MAP) outside of an individual's cerebral autoregulation (CA) limits using near-infrared spectroscopy (NIRS) and transcranial Doppler (TCD) are associated with adverse neurological events. It is to investigate whether patients with a higher burden of cerebral haemodynamic insults have an increased incidence or poorer neurological outcomes. Associations between neurologic outcomes, neurobiomarkers and genetic tests will be explored.

Key facts

Study ID

NCT05595954

Run by

University Hospital, Basel, Switzerland

People needed

500

Starts

2023-01-23

Expected to finish

2027-06-01

Last updated by the study team

2026-06-30

Who can join

Age: 65 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Elective primary or reoperative coronary artery bypass graft and/or valvular and/or ascending aorta surgery requiring cardiopulmonary bypass.

You may not qualify if…

• Surgery requiring moderate (28-31.9ºC) or deep (<28ºC) hypothermic circulatory arrest;
• Heart and/or lung transplantation;
• Urgent (within 24 hours) and emergency surgery;
• Inability to follow procedures or insufficient knowledge in English, German or French;
• Inability to give consent.
• Participants who undergo cardiac surgery under minimal extracorporeal circulation will also be excluded.

Where it is running

• Inselspital, Bern University Hospital — Bern, Switzerland (enrolling)
• Clinic for Anaesthesia, Intermediate Care, Prehospital Emergency Medicine and Pain Therapy, University Hospital Basel — Basel, Switzerland
• Cambridge University Hospitals and Brain Physics Lab — Cambridge, United Kingdom
• Royal Papworth Hospital, Department of Anaesthesia and Intensive Care — Cambridge, United Kingdom

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.