Fisetin to Improve Physical Function in Stage I-III Breast Cancer Survivors

Recruiting now · Phase 2 · Has a placebo group

Conditions studied: Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8

In brief

This phase II trial tests whether fisetin works to improve physical function in women who have received chemotherapy for stage I-III breast cancer treatment. Fisetin is a naturally occurring substance that is found in strawberries and other foods. Fisetin eliminates cells that have undergone a process called senescence. Senescence is when a cell ages and permanently stops dividing but does not die. Over time, large numbers of these cells build up in tissues throughout the body and can release harmful substances that causes inflammation and damages nearby healthy cells. Studies have shown that chemotherapy causes a build-up of these senescent cells. Giving fisetin may eliminate senescent cells and improve physical function in postmenopausal women who have received chemotherapy for breast cancer.

Key facts

Study ID: NCT05595499
Run by: Jonsson Comprehensive Cancer Center
People needed: 88
Starts: 2023-03-27
Expected to finish: 2028-08-14
Last updated by the study team: 2026-07-17

Who can join

Age: any. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

Women who are postmenopausal at the start of study treatment.
Postmenopausal status will be established as follows:
Women aged: >= 60 years OR
Women aged < 60 years AND one of the following conditions is met:
They have not had any menstrual periods for at least 12 months in the absence of exogenous hormonal treatments, chemotherapy, and/or tamoxifen AND have serum estradiol and follicle-stimulating hormone (FSH) levels confirmed as being within the standard laboratory reference range for postmenopausal females.
They have documented irreversible bilateral oophorectomy.
They are receiving ovarian suppression with their breast cancer endocrine therapy
Women with a diagnosis of early-stage breast cancer (Stage I-III) treated with neo/adjuvant chemotherapy within 12 months of starting study treatment
No evidence of active/recurrent breast cancer or other serious chronic illnesses
Have evidence of frail health, defined as a diminished 6-minute walk distance (< 400m) at baseline
Platelets > 60,000/mm\^3
White blood cell count > 2,000/mm\^3
Absolute neutrophil count > 500/mm\^3
Hemoglobin >= 8.0 g/dL
Total bilirubin =< 3.0 X upper limit of normal (ULN)
Aspartate aminotransferase (AST) =< 4.0 x ULN
Alanine aminotransferase (ALT) =< 4.0 x ULN
Estimated glomerular filtration rate (eGFR) of >= 30mL/min/1.73m\^2 per the Modification of Diet in Renal Disease (MDRD) calculation
Ability to understand and the willingness to sign a written informed consent document

You may not qualify if…

Cancer-directed chemotherapy, biological therapy, or immunotherapy within 30 days prior to the start of study treatment. Exceptions include: trastuzumab, pertuzumab, pembrolizumab, tamoxifen, ribociclib, abemaciclib, aromatase inhibitors and/or ovarian suppression.
Surgery and/or radiation within the last 30 days of starting study treatment (Exception: invasive non- major procedures such as an outpatient biopsy)
Subjects taking medications that are considered prohibited.
Exception: Subjects taking any of the medications listed in under "Temporary medication adjustment required" may participate if they are otherwise eligible AND the medication can be safely withheld (from immediately before the 1st study agent administration until at least 10 hours after the last study agent administration, for each dosing interval)
On herbal and natural medications with possible senolytic properties (i.e., curcumin, kava kava, St. John's wort) and are unable or unwilling to hold its administration 2 days prior to and during study treatment dosing. Exceptions include cannabidiol (CBD), vitamins, probiotics, and fish oil. Other herbal and natural medications may be permitted or prohibited per clinician discretion
Subjects taking potentially senolytic agents within the last year: fisetin, quercetin, luteolin, dasatinib or imatinib (or other tyrosine kinase inhibitors), piperlongumine, or navitoclax
Subjects on therapeutic doses of anticoagulants (e.g., warfarin, heparin, low molecular weight heparin, factor Xa inhibitors, etc.)
Issues with tolerating oral medication (such as but not limited to, inability to swallow pills (g-tubes not allowed), malabsorption issues, ongoing nausea or vomiting during screening, history of Crohn's, gastric bypass/reduction, or celiac disease)
Any other condition that would, in the Investigator's judgment, contraindicate the patient's participation in the clinical study due to safety concerns with clinical study procedures
Currently participating in another intervention research study seeking to improve functional status, alleviate frailty, muscle strength, exhaustion/fatigue, or cognitive function

Where it is running

UCLA Health Cancer Care in Alhambra — Alhambra, California, United States (enrolling)
UCLA Health Beverly Hills Primary & Specialty Care — Beverly Hills, California, United States (enrolling)
UCLA Health Burbank Primary & Specialty Care — Burbank, California, United States (enrolling)
City of Hope Comprehensive Cancer Center — Duarte, California, United States (enrolling)
UCLA / Jonsson Comprehensive Cancer Center — Los Angeles, California, United States (enrolling)
UCLA Health Primary Care in Marina del Rey — Marina del Rey, California, United States (enrolling)
UCLA Health Primary Care in Pasadena — Pasadena, California, United States (enrolling)

Full record on ClinicalTrials.gov

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