Role of Autophagy in Type 2 Diabetes Microvascular Dysfunction
Recruiting now · Early Phase 1 · Has a placebo group
Conditions studied: Type 2 Diabetes, Healthy Aging
In brief
The goal of this clinical trial is to examine the role of autophagy on microvascular function in adults with Type 2 Diabetes. The main question it aims to answer are: * Does presence of Type 2 Diabetes reduce autophagy and impair microvascular function? * Does exposure to high glucose impair autophagy and subsequently microvascular function? Participants will undergo 2 study days. The primary outcome will be in vivo microvascular function testing. Following the first study day participants will undergo either supplementation with trehalose, an autophagy activator, or placebo for 14 days. The second study day will test in vivo microvascular function.
Key facts
- Study ID
- NCT05593549
- Run by
- Medical College of Wisconsin
- People needed
- 60
- Starts
- 2023-01-01
- Expected to finish
- 2029-12-31
- Last updated by the study team
- 2025-10-30
Who can join
Age: 18 and older, up to 80. Sex: any. Healthy volunteers: accepted.
You may not qualify if…
- Uncontrolled hypertension
- Current Tobacco use or within last 6 months
- BMI > 35
- Hyperlipidemia
- Hypercholesterolemia
- Type 1 Diabetes
- Use of anti-coagulant drugs, or anti-platelet drugs
- Symptomatic coronary artery disease
- Heart Failure
- Renal Impairment
- Hormone Replacement Therapy
- History of Retinopathy
- Documented Neuromuscular Disorders
- Porphyria Cutanea Tarda (blistering of skin to sun; photosensitivity)
- Pregnancy (Young Female subjects)
- Allergies to Povidone Iodine
- Use Erectile Dysfunction Medication in the past 6 months
- Use of Topical/non-topical Steroids in last 6 months
- Active Anti-Cancer Treatment or Treatment within last 12 months
- Active COVID-19 or within the past 3 months
- Gender Reassignment Therapy
Where it is running
- Medical College of Wisconsin — Milwaukee, Wisconsin, United States (enrolling)
Full record on ClinicalTrials.gov
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