Evaluation of the Effectiveness of an Amnion-chorion Membrane for Alveolar Ridge Preservation

Completed · Not applicable

Conditions studied: Healing Wound

In brief

This study will examine whether adding an amnion-chorion membrane on top of the traditionally used collagen plug will lead to more bone formation compared to the collagen plug only.

Key facts

Study ID

NCT05592158

Run by

University of Michigan

People needed

30

Starts

2022-11-16

Expected to finish

2025-02-14

Last updated by the study team

2025-03-25

Who can join

Age: 20 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age range: 20 to 80 years.
• Patients must require tooth extraction (for incisors, canines and premolars) as a result of caries, periodontal disease, tooth fracture or deemed unrestorable.
• Socket should be free of infection, less than 5mm of dehiscence
• Patients interested in implant placement following tooth extraction.

You may not qualify if…

• Allergies or hypersensitivities to study related medications such as chlorhexidine.
• Hematologic disorders/blood dyscrasias.
• Active infectious diseases of any kind.
• Liver or kidney dysfunction/failure.
• Uncontrolled diabetes (HbA1c > 8).
• Active cancer treatment - such as active chemotherapy or radiation therapy.
• Taking medications that will affect their bone healing (for example, bisphosphonates).
• Metabolic bone diseases that affect bone healing such as osteoporosis.
• Pregnant or lactating women (self-reported).
• Smoke 10 or more cigarettes per day (self-reported).
• Poor oral hygiene.

Where it is running

• University of Michigan School of Dentistry — Ann Arbor, Michigan, United States

Full record on ClinicalTrials.gov

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