Role of Candidate Proteins in Capillary Leakage During Acute Circulatory Failure
Recruiting now
Conditions studied: Cardiogenic Shock, Postresuscitation Disease, Septic Shock
In brief
* Testing the association between circulating candidate proteins and the level of vascular leakage for three distinct forms of circulatory failure: cardiogenic shock, septic shock, and post-resuscitation syndrome. * Describing immuno-inflammatory profiles associated with massive vascular leakage during those three forms of circulatory failure in humans
Key facts
- Study ID
- NCT05586282
- Run by
- Assistance Publique - Hôpitaux de Paris
- People needed
- 380
- Starts
- 2023-03-20
- Expected to finish
- 2026-04-01
- Last updated by the study team
- 2024-10-15
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Informed consent from patient or a legal representative/family member/close relative. The patient will be asked to give his/her consent for the continuation of the trial when his/her condition will allow.
- Affiliation to social security (AME excluded)
- Patient with one of the circulatory failures described below:
- septic shock
- cardiogenic shock
- post-resuscitation syndrome
- Cardiogenic shock:
- Need for a catecholamine support to maintain mean arterial pressure>65 mmHg, AND
- Cardiac index <2 L/min/m2 or left ventricular ejection fraction (LVEF)<35%, AND
- Lactate >2.0 mmol/l
- Post-resuscitation syndrome:
- Cardiac arrest (absence of spontaneous respiration, palpable heartbeat, and responsiveness to stimuli> 1 min) with a compatible electrocardiogram (asystole/pulseless electrical activity/ventricular tachycardia), AND
- Need for a catecholamine support to maintain mean arterial pressure>65 mmHg, AND
- Lactate >2.0 mmol/l
- Septic shock:
- Suspected or proven bacterial infection
- Need for a vasopressor support to maintain mean arterial pressure>65 mmHg
- Lactate >2.0 mmol/l
- Cardiac index>3L/min/m2 or LVEF>40%
You may not qualify if…
- Onset of shock (catecholamine infusion) >12 hours prior to inclusion
- Age <18 year old
- Pregnancy
Where it is running
- Hôpital Européen Georges Pompidou — Paris, France (enrolling)
Full record on ClinicalTrials.gov
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