Engage & Connect: A Psychotherapy for Postpartum Depression

Recruiting now · Not applicable

Conditions studied: Postpartum Depression

In brief

This randomized controlled trial compares a novel psychotherapy, Engage \& Connect, with a Symptom Review and Psychoeducation intervention, tailored to reduce postpartum depression. The study includes 9-weeks interventions, delivered remotely. It will examine changes in social isolation, processing of social rewards and depression severity over 9 weeks of treatment.

Key facts

Study ID: NCT05585164
Run by: Weill Medical College of Cornell University
People needed: 60
Starts: 2022-11-01
Expected to finish: 2030-07-01
Last updated by the study team: 2025-09-25

Who can join

Age: any. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

Up to 1 year post-delivery
Edinburgh Postnatal Depression Scale (EPDS) score ≥ 10.
Off antidepressants or on a stable dose of an antidepressant for 8 weeks and do not intend to change the dose in the next 10 weeks.
Capacity to provide consent for research assessment and treatment.
Speaks English proficiently

You may not qualify if…

Intent or plan to attempt suicide in the near future
Ongoing psychotherapy (no more than once every 8 weeks or during the duration of the intervention)
Active substance abuse or dependence
Severe fetal anomalies, stillbirth or infant death at time of enrollment for index pregnancy
History or presence of psychiatric diagnoses other than major depressive disorder without psychotic features, generalized anxiety disorder, persistent depressive disorder, or specific phobia.
Use of psychotropic drugs or cholinesterase inhibitors other than use of ≤ 0.5 mg of lorazepam daily up to seven times per week.

Where it is running

Weill Cornell Medicine — New York, New York, United States (enrolling)

Full record on ClinicalTrials.gov

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