Cellulitis Optimal Antibiotic Treatment

Recruiting now · Phase 3 · Has a placebo group

Conditions studied: Cellulitis of Leg

In brief

To determine whether a short course of oral flucloxacillin (5 days) is non-inferior to a standard course (7 days) in terms of pain over days 6-14 (indicative of persistence or recurrence associated with the symptoms of most importance to patients) in adults with cellulitis of the leg presenting in primary care.

Key facts

Study ID

NCT05584007

Run by

University of Southampton

People needed

334

Starts

2023-08-29

Expected to finish

2027-07-01

Last updated by the study team

2026-05-15

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Must be aged 18 years or older
• Currently showing symptoms of cellulitis (such as pain, tenderness, redness, other change in skin color, warmth to touch) in one leg for 10 days or less
• Pain rated as 3/10 or higher on a numerical rating scale (0-10) at baseline assessment
• Be willing to be randomized to either trial arm (5-day or 7-day treatment)
• Able to complete trial procedures in the English language.

You may not qualify if…

• Have penicillin allergy
• Have bilateral cellulitis
• Have had antibiotics for cellulitis within the past month
• Have post-operative cellulitis (within 30 days of operative procedures on the same leg)
• Have cellulitis resulting from human/animal bite injury
• Have Cellulitis associated with chronic (>6 weeks) leg ulceration
• Require immediate hospital admission or out-patient intravenous antibiotic therapy

Where it is running

• Royal South Hants Hospital — Southampton, United Kingdom (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.