Relationship Between Abnormal Myocardial Perfusion and Diastolic Dysfunction in Sickle Cell Disease Using PET

Recruiting now · Phase 2

Conditions studied: Sickle Cell Disease

In brief

There is limited information on what causes injury to the heart in individuals with Sickle Cell Disease (SCD). Researchers in this study want to see if decreased blood flow to the heart during stress could be causing the heart damage seen in SCD patients. They also want to test people who don't have SCD to see if their hearts react the same way under stress. Primary Objective * To estimate the coronary flow reserve (CFR) (also referred to as myocardial perfusion reserve), as measured by PET stress-rest myocardial perfusion imaging, in SCD patients with and without diastolic dysfunction, and healthy controls. Secondary Objectives * To investigate the relationship between decreased CFR (quantified with PET stress- rest myocardial perfusion imaging) and presence of abnormal diastolic parameters

Key facts

Study ID
NCT05583721
Run by
St. Jude Children's Research Hospital
People needed
40
Starts
2023-10-10
Expected to finish
2028-09-01
Last updated by the study team
2026-05-06

Who can join

Age: 18 and older, up to 21. Sex: any. Healthy volunteers: accepted.

Where it is running

Full record on ClinicalTrials.gov

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