Thyroid Function and Structure in Klinefelter Syndrome

Recruiting now

Conditions studied: Klinefelter Syndrome, Thyroiditis, Autoimmune, Hypothyroidism

In brief

This is a longitudinal retrospective study for the evaluation of thyroid function and structure in patients with Klinefelter syndrome compared to healthy controls and patients affected by chronic lymphocytic thyroiditis.

Key facts

Study ID

NCT05581147

Run by

University of Roma La Sapienza

People needed

600

Starts

2007-05-11

Expected to finish

2026-12-01

Last updated by the study team

2025-03-30

Who can join

Age: 1 and older, up to 80. Sex: male. Healthy volunteers: not accepted.

You may qualify if…

• Patients with a confirmed diagnosis of classic, non-mosaic 47,XXY Klinefelter syndrome based on a peripheral blood 97 karyotype analysis;
• Availability of thyroid function test results (TSH, fT3, and fT4) and/or thyroid US imaging;
• Availability of concurrent clinical data.

You may not qualify if…

• Presence of other known genetic conditions or chromosomal abnormalities;
• Use of levothyroxine or other drugs that are either active on the hypothalamic-pituitary-thyroid (HPT) axis or that may interfere with thyroid function tests;
• History of previous surgery or radiotherapy on the thyroid or pituitary glands;
• Current or previous T therapy (for the pre-pubertal and pubertal groups).

Where it is running

• 'Sapienza' University of Rome — Roma, Italy (enrolling)

Full record on ClinicalTrials.gov

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