Reducing Mortality in Adults With Advanced HIV Disease (REVIVE)
Recruiting now · Phase 3 · Has a placebo group
Conditions studied: HIV Disease Progression
In brief
A double blinded, placebo-controlled, multicenter trial to evaluate effectiveness of azithromycin prophylaxis on mortality in advanced HIV.
Key facts
- Study ID
- NCT05580666
- Run by
- Population Health Research Institute
- People needed
- 8000
- Starts
- 2023-05-08
- Expected to finish
- 2029-05-31
- Last updated by the study team
- 2025-09-03
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age ≥ 18 years
- Documented HIV infection
- CD4 count criteria:
- i. CD4 count ≤ 100 cells/mm3 within past 4 weeks; or
- ii. Documented CD4 nadir ≤ 100 cells/mm3 and complete interruption of ART for ≥ 6 months; or
- iii. Documented CD4 count ≤ 100 cells/mm3 if ART-naive
- Ability to initiate or re-initiate ART, or switch to an effective ART regimen if failing current therapy, within 4 weeks of enrolment
You may not qualify if…
- Contraindications to azithromycin:
- i. Hypersensitivity to azithromycin, erythromycin, or any macrolide antibiotic; or
- ii. Personal or family history of QT-prolongation
- Severe illness requiring immediate or continued hospitalization (this will be in the judgment of site investigators)
- Off-label azithromycin prophylaxis or requirement for prolonged (> 7 days) azithromycin (or macrolide) therapy
Where it is running
- University College Hospital — Ibadan, Nigeria (enrolling)
- Lagos University Teaching Hospital — Lago, Nigeria (enrolling)
- Asella Referral and Teaching Hospital — Āsela, Ethiopia (enrolling)
- University of Nigeria Teaching Hospital — Enugu, Nigeria (enrolling)
- Koidu Government Hospital — Koidu, Sierra Leone (enrolling)
- 34 Military Hospital — Freetown, Sierra Leone (enrolling)
- Adama Hospital Medical College — Ādama, Ethiopia (enrolling)
- New Somerset Hospital — Cape Town, South Africa (enrolling)
- Ubuntu Clinic, Site B, Khayelitsha, Wellcome Centre — Cape Town, South Africa (enrolling)
- Suntreso Government Hospital — Kumasi, Ghana (enrolling)
- College of Medicine and Allied Health Sciences, University of Sierra Leone — Freetown, Sierra Leone (enrolling)
- Kenema Regional Hospital — Kenema, Sierra Leone (enrolling)
- Livingstone hospital — Port Elizabeth, South Africa (enrolling)
- Steve Biko Academic Hospital, University of Pretoria — Pretoria, South Africa (enrolling)
- Wits Health Consortium (Pty) Ltd — Johannesburg, South Africa (enrolling)
- Makeni Regional Hospital — Makeni, Sierra Leone (enrolling)
- MUJHU — Kampala, Uganda (enrolling)
- SICRA Kampala — Kampala, Uganda (enrolling)
- SICRA Lira — Lira, Uganda (enrolling)
- Mbarara Regional Referral hospital — Mbarara, Uganda (enrolling)
- Jimma University Hospital — Jimma, Ethiopia (enrolling)
- Kumasi South Hospital — Kumasi, Ghana (enrolling)
- Africa Health Research Institute (AHRI)- Hluhluwe Clinic — Hluhluwe, South Africa
- Africa Health Research Institute (AHRI)- Somkhele Clinic — Mtubatuba, South Africa
- Centre Intégré de Recherches Biocliniques d'Abidjan (CIRBA) — Abidjan, Côte d’Ivoire
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.