A Clinical Study of MK-1045 (CN201) in People With Precursor B-cell Acute Lymphoblastic Leukemia (MK-1045-002)
Recruiting now · Phase 1/Phase 2
Conditions studied: Acute Lymphoblastic Leukemia
In brief
Researchers are looking for new ways to treat people with a type of blood cancer called precursor B-cell Acute Lymphoblastic Leukemia (B-ALL) that is relapsed- the cancer has come back after treatment, or refractory - the current treatment has stopped working to slow or stop cancer growth. This study will have two parts. In the first part (dose escalation phase) the goal is to learn about the safety of a study treatment, MK-1045, and to find the best dose level of MK-1045 that is tolerated and may work to treat B-ALL. In the second part (Phase II) researchers want to learn how well MK-1045 works to treat B-ALL.
Key facts
- Study ID
- NCT05579132
- Run by
- MSD R&D (China) Co., Ltd.
- People needed
- 203
- Starts
- 2022-11-01
- Expected to finish
- 2028-06-30
- Last updated by the study team
- 2026-07-13
Who can join
Age: 2 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- The Second Affiliated Hospital of Third Military Medical University ( Site 0008) — Chongqing, Chongqing Municipality, China (enrolling)
- Southern Medical University Nanfang Hospital ( Site 0004) — Guangzhou, Guangdong, China (enrolling)
- The Second Hospital of Hebei Medical University ( Site 0003) — Shijiazhuang, Hebei, China (enrolling)
- The First Hospital of Harbin ( Site 0005) — Harbin, Heilongjiang, China (enrolling)
- Henan Cancer Hospital-hematology department ( Site 0002) — Zhengzhou, Henan, China (enrolling)
- Union Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology ( Site 0010) — Wuhan, Hubei, China (enrolling)
- Tongji Hospital affiliated to Tongji Medical College of HUST ( Site 0006) — Wuhan, Hubei, China (enrolling)
- Hematology Hospital of Chinese Academy of Medical Sciences ( Site 0001) — Tianjin, Tianjin Municipality, China (enrolling)
- West China Second University Hospital, Sichuan University ( Site 0011) — Chengdu, Sichuan, China
- The Children's Hospital of Zhejiang University School of Medicine ( Site 0009) — Hangzhou, Zhejiang, China
- The Affiliated Hospital of Xuzhou Medical University ( Site 0007) — Xuzhou, Jiangsu, China
Full record on ClinicalTrials.gov
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