V/Q Matching Variations With PEEP in ARDS According to Compliance-based Phenotypes (France)

Recruiting now · Not applicable

Conditions studied: ARDS

In brief

This study aim to compare the effect of Positive End Expiratory Pressure (PEEP) on ventilation/perfusion mismatch in two phenotypes of patients with moderate-to-severe Acute Respiratory Distress Syndrome (ARDS), characterized by their respiratory system elastance (Ers). Ventilation/perfusion mismatch will be assessed by Electrical Impedance Tomography (EIT).

Key facts

Study ID

NCT05578742

Run by

University Hospital, Angers

People needed

50

Starts

2024-02-08

Expected to finish

2026-09-01

Last updated by the study team

2025-12-08

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• intubated patients with moderate and severe ARDS (Berlin definition, PaO2/FiO2 ≤200 mmHg at PEEP 5 cmH2O)
• undergoing deep sedation
• on controlled mechanical ventilation
• between 24 hours and 5 days after intubation.

You may not qualify if…

• age <18 years old; pregnancy
• patient undergoing legal protection
• contra-indications to EIT (e. g. severe chest trauma or wounds)
• pneumothorax; patient undergoing ECMO
• patient with BMI ≥35 kg/m2
• hemodynamic instability with MAP <60 mmHg despite vasopressors.

Where it is running

• Angers Hospital — Angers, Maine et Loire, France (enrolling)

Full record on ClinicalTrials.gov

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