A Pilot Study for Optimizing Meropenem Administration in the ICU

Recruiting now · Not applicable

Conditions studied: Drug Effect

In brief

Can antibiotic drugs be administered faster and make acceptable serum concentrations if we give short but multiple infusions compared to long and fewer infusions? In this study we will compare giving meropenem 1 gram 6 times daily in 15 minutes infusions to the recommended 2 gram 3 times daily in 3 hours infusions. In patients in the intensive care unit, the need for intravenous access is of essence. If 6 short infusions results in the same serum concentrations as 3 long infusions, we will increase intravenous access from 15 to 22.5 hours daily.

Key facts

Study ID

NCT05578586

Run by

Oslo University Hospital

People needed

50

Starts

2021-12-14

Expected to finish

2027-06-01

Last updated by the study team

2025-04-24

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients ≥ 18 years admitted to the ICU at Oslo University Hospital, Rikshospitalet and
• who shall be treated with meropenem because of proven or suspected serious infection and
• who give their written informed consent either directly or through next of kin
• Exclusion Criteria: Patients
• with known hypersensistivity to betalactam antibiotics or
• who use of valproat or
• who are pregnant or
• the lack of consent.

Where it is running

• Oslo University Hospital — Oslo, Norway (enrolling)

Full record on ClinicalTrials.gov

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