Natural History of Cerebral Palsy Prospective Study

Recruiting now

Conditions studied: Cerebral Palsy

In brief

The study will describe the natural history of cerebral palsy (CP) as children develop over the first 2 years of life.

Key facts

Study ID

NCT05576948

Run by

Children's Hospital Medical Center, Cincinnati

People needed

100

Starts

2022-09-08

Expected to finish

2027-09-08

Last updated by the study team

2025-09-25

Who can join

Age: 0 and older, up to 2. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Infants will be included if they have a diagnosis of CP or "at high risk of CP" and under the age of 12 months.
• Infants at high risk of CP as defined by any two (any combination) of the following:
• Neuroimaging predictive of a motor disability including the involvement of 1 or more of the following structures: sensori-motor cortex, Basal Ganglia, Posterior Limb of the Internal Capsule, pyramids.
• Trajectory of cramped synchronized general movements (GMs) on General Movement Assessment (GMA) OR absent fidgety GMs at fidgety age
• Hammersmith Infant Neurological Exam (HINE) scores <57 @ 3months or <60 @ 6months or <63 @9 months
• Infants will also be included if they meet BOTH of the following criteria (even if infants have a HINE score greater than the cut off scores stated above:
• i. Unilateral brain injury on neuroimaging (magnetic resonance imaging (MRI) or cranial ultrasound (CUS)) predictive of CP ii. Clinical signs of asymmetry

You may not qualify if…

• Infants with progressive or neurodegenerative disorders or genetic disorders not associated with CP
• Infants with other disability diagnoses e.g. Down Syndrome

Where it is running

• Cincinnati Children's Hospital Medical Center — Cincinnati, Ohio, United States (enrolling)

Full record on ClinicalTrials.gov

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