Longitudinal Prospective Study of Neurocognition & Neuroimaging in Primary BT Patients

Recruiting now

Conditions studied: Primary Brain Tumor, Glioma, Meningioma, Schwannoma

In brief

In this proposal, the investigators introduce a novel, translational study to prospectively examine primary brain tumor patients undergoing fractionated radiation therapy to the brain. Quantitative neuroimaging, radiation dose information, and directed neurocognitive testing will be acquired through this study to improve understanding of cognitive changes associated with radiation dosage to non-targeted tissue, and will provide the basis for evidence-based cognitive- sparing brain radiotherapy.

Key facts

Study ID

NCT05576103

Run by

Jona Hattangadi-Gluth

People needed

300

Starts

2015-01-01

Expected to finish

2030-12-01

Last updated by the study team

2026-06-10

Who can join

Age: 18 and older, up to 99. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients 18 years or older
• Karnofsky performance status (KPS) ≥70
• Life expectancy of ≥1 year
• Primary brain tumor patients who will receive fractionated partial brain RT
• Able to complete neurocognitive assessments

You may not qualify if…

• Inability to undergo MRI with contrast
• Prior brain RT

Where it is running

• Moores Cancer Center — San Diego, California, United States (enrolling)

Full record on ClinicalTrials.gov

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