1/2- Bangladesh Center for Global Environmental and Occupational Health- Bangladesh

Recruiting now · Not applicable

Conditions studied: Air Pollution, mHealth Intervention, Cardiopulmonary Function, Immune Function

In brief

Almost 3 billion people worldwide, including 89% people in Bangladesh, are exposed to harmful household air pollutants (HAP) emitted from combustion of biomass (wood, agricultural residue, cow dung, etc.) fuel use for cooking. While health risks associated with air-pollution have been reasonably well-studied in developed countries, there is little evidence on health benefits achievable by HAP reduction through clean fuel use, especially in low- and middle-income countries (LMICs). Earlier the investigators showed that Liquid Petroleum Gas (LPG) for 24 months, reduced personal PM2.5 exposure by 58.17 percent which induced novel changes in immune and inflammatory responses in the participants; however cardiopulmonary markers remained relatively stable in post-intervention assessment. In this study, the investigators aim to evaluate the effects of mobile phone based (mHealth) Behavioural Change Communication (BCC) intervention on adoption and exclusive use of LPG. The investigators also aimed to observe whether long-term effects of HAP reduction can impact the subclinical measures of cardio-vascular and pulmonary dysfunction and regulate innate and inflammatory immune function among women and children in semi-rural settings in Bangladesh. The investigators will also investigate the influence of exposure to HAP on antibody response to vaccines (adaptive immunity). The BCC intervention will be provided by conducting a large household level randomized controlled trial by educational intervention using mHealth based technology. In addition, the investigators will continue following the cohort and will conduct rigorous and repeated personalized (24 hours) and area (over 5 days) assessments of PM2.5 and black carbon (BC) exposure to examine the long-term effects of HAP reduction on subclinical measures of cardio-pulmonary and immune dysfunction including effect of HAP exposure on antibody response to vaccine.

Key facts

Study ID

NCT05570552

Run by

International Centre for Diarrhoeal Disease Research, Bangladesh

People needed

1000

Starts

2023-06-20

Expected to finish

2027-06-01

Last updated by the study team

2024-03-22

Who can join

Age: 25 and older, up to 70. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Participants in the previous GEOHEALTH round-I study
• Aged between 25 and 70 years
• Live in biomass-using home with traditional stoves
• Non-smoker and live with non-smokers
• Exposed to <10 µg/L of water arsenic

You may not qualify if…

• Known to have immune related illness or taking any prescription medication (particularly those that suppress or enhance immune function)
• Known to have any clinical events of CVD or lung disease, including stroke or coronary heart disease.

Where it is running

• International Centre for Diarrhoeal Diseases Research, Bangladesh — Dhaka, Bangladesh (enrolling)

Full record on ClinicalTrials.gov

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