A Study of Zetomipzomib (KZR-616) in Patients With Autoimmune Hepatitis (PORTOLA)
Completed · Phase 2 · Has a placebo group
Conditions studied: Autoimmune Hepatitis
In brief
This was a Phase 2a, multi-center, placebo-controlled study in which patients with autoimmune hepatitis received zetomipzomib or placebo in addition to standard-of-care for 24 weeks; an optional open-label extension period allowed participants to receive zetomipzomib (KZR-616) for an additional 24 weeks of treatment.
Key facts
- Study ID
- NCT05569759
- Run by
- Kezar Life Sciences, Inc.
- People needed
- 24
- Starts
- 2023-05-23
- Expected to finish
- 2025-04-30
- Last updated by the study team
- 2026-01-13
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Mayo Clinic Arizona — Phoenix, Arizona, United States
- Keck School of Medicine of USC — Los Angeles, California, United States
- University of California, Los Angeles — Los Angeles, California, United States
- Stanford Medicine — Redwood City, California, United States
- California Pacific Medical Center — San Francisco, California, United States
- University of California, San Francisco — San Francisco, California, United States
- University of Colorado — Aurora, Colorado, United States
- Yale University — New Haven, Connecticut, United States
- Mayo Clinic Florida — Jacksonville, Florida, United States
- University of Miami — Miami, Florida, United States
- Northwestern University — Chicago, Illinois, United States
- Rush University — Chicago, Illinois, United States
- Indiana University — Indianapolis, Indiana, United States
- Ochsner Clinic Foundation — New Orleans, Louisiana, United States
- Massachusetts General Hospital — Boston, Massachusetts, United States
- Beth Israel Deaconess Medical Center — Boston, Massachusetts, United States
- University of Michigan Medical Center — Ann Arbor, Michigan, United States
- Washington University School of Medicine — St Louis, Missouri, United States
- Northwell Health Center for Liver Disease and Transplantation — Manhasset, New York, United States
- New York University Langone Health/Grossman School of Medicine — New York, New York, United States
- Duke University Medical Center — Durham, North Carolina, United States
- University Hospitals Cleveland Medical Center — Cleveland, Ohio, United States
- University of Pennsylvania — Philadelphia, Pennsylvania, United States
- Virginia Commonwealth University — Richmond, Virginia, United States
Full record on ClinicalTrials.gov
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