Reducing Antimicrobial Overuse Through Targeted Therapy for Patients With Community-Acquired Pneumonia

Completed · Not applicable

Conditions studied: Community-Acquired Pneumonia, Antimicrobial Stewardship, Point-of-Care Testing

In brief

The purpose of this study is to reduce the exposure of broad-spectrum antimicrobials by optimizing the rapid detection of CAP pathogens and improving rates of de-escalation following negative cultures. To accomplish this, we will perform a 3-year, pragmatic, multicenter 2 X 2 factorial cluster randomized controlled trial with four arms: a) rapid diagnostic testing b) pharmacist-led de-escalation c) rapid diagnostic testing + pharmacist-led de-escalation and d) usual care

Key facts

Study ID

NCT05568654

Run by

The Cleveland Clinic

People needed

28580

Starts

2022-11-01

Expected to finish

2026-06-30

Last updated by the study team

2026-07-01

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may not qualify if…

• Admission to intensive care unit within 24 hours of hospital admission
• Comfort care measures only
• Cystic fibrosis
• Discharged from an acute care hospital in the past week
• Patients not eligible for empiric therapy due to a known pathogen (any positive blood or respiratory cultures in the 72 hours prior to admission)

Where it is running

• Indian River Hospital — Vero Beach, Florida, United States
• Weston Hospital/Cleveland Clinic Florida — Weston, Florida, United States
• Akron General Hospital — Akron, Ohio, United States
• Avon Hospital — Avon, Ohio, United States
• Lutheran Hospital — Cleveland, Ohio, United States
• Cleveland Clinic Main Campus — Cleveland, Ohio, United States
• Euclid Hospital — Euclid, Ohio, United States
• Fairview Hospital — Fairview Park, Ohio, United States
• Marymount Hospital — Garfield Heights, Ohio, United States
• Hillcrest Hospital — Mayfield Heights, Ohio, United States
• Medina Hospital — Medina, Ohio, United States
• South Pointe Hospital — Warrensville Heights, Ohio, United States

Full record on ClinicalTrials.gov

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