Efficacy of Reading Intervention on the Brain Connectivity in Autism
Status unconfirmed · Early Phase 1
Conditions studied: Autism Spectrum Disorder, Autism, Reading Problem
In brief
The overarching goal of this proposal is to test the impact of a comprehensive reading intervention program (Visualizing and Verbalizing) on changing the neurobiological mechanisms underlying reading comprehension deficits in children with autism spectrum disorders (ASD). To this end, the investigators will test a group of children with ASD and NT control participants who share common characteristic of average level decoding along with below average reading comprehension. Inclusion of an additional NT group that does not have any reading comprehension deficit will provide another control for additional comparisons.
Key facts
- Study ID
- NCT05568056
- Run by
- University of Alabama, Tuscaloosa
- People needed
- 200
- Starts
- 2019-01-10
- Expected to finish
- 2024-08-31
- Last updated by the study team
- 2023-12-01
Who can join
Age: 7 and older, up to 13. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Full Scale and Verbal IQs > 70
- be 7-13 years of age;
- no antipsychotics for at least one month
- no anti-epileptics/convulsants for at least one week
- no stimulants for 24 hours prior to testing; and
- subjects with ASD meet DSM-V criteria (American Psychiatric Association, 2013)
- Neurotypical participants will be medically healthy (below ASD symptom cutoff score on the SCQ (Rutter, Bailey, \& Lord, 2003); without a self-reported and parent- reported history of neurologic or psychiatric disorders; and without a family history of ASD)
- The NT-EXP participants need to have similar profile of reading comprehension difficulties as the ASD participants with average decoding accompanied by below average reading comprehension.
You may not qualify if…
- contraindication for MRI (cardiac pacemaker, aneurysm clip, cochlear implants, Intra Uterine Device, shrapnel, neurostimulators, defibrillator, artificial heart valve, or history of metal fragments in eyes, pregnancy, a body weight of more than 250 lbs. and claustrophobia)
- seizure disorder or history of head injury
Where it is running
- University of Alabama — Tuscaloosa, Alabama, United States (enrolling)
Full record on ClinicalTrials.gov
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