Anti-Platelets in Chronic Obstructive Pulmonary Disease
Completed · Phase 2 · Has a placebo group
Conditions studied: COPD, Emphysema, Emphysema or COPD
In brief
This is a 6 week crossover study in current and former smokers with and without COPD to evaluate whether 2 weeks of dual antiplatelet therapy (aspirin 81mg and clopidogrel 75mg) improves pulmonary perfusion (i.e. blood flow in the lungs measured on a contrast CT scan) compared to placebo.
Key facts
- Study ID
- NCT05567562
- Run by
- Brigham and Women's Hospital
- People needed
- 15
- Starts
- 2024-03-27
- Expected to finish
- 2025-02-28
- Last updated by the study team
- 2026-05-14
Who can join
Age: 50 and older, up to 80. Sex: any. Healthy volunteers: accepted.
You may not qualify if…
- Platelet count < 150,000/dL or self-report of a bleeding disorder;
- Regular use of aspirin, clopidogrel or another antiplatelet medication;
- Allergy to aspirin, clopidogrel, albuterol or iodine/IV contrast;
- BMI > 35;
- History of intracranial hemorrhage, severe GI bleed or other life-threatening bleed;
- Use of blood thinner (e.g. warfarin, lovenox or novel oral anti-coagulants);
- Continuous use of supplemental oxygen at home;
- Regular use of an NSAID;
- Daily use of oral steroids, theophylline, roflumilast, or loop diuretics;
- History of organ transplant or autoimmune disease on systemic therapy (rheumatoid arthritis, lupus);
- Use of a biologic medication with regular injections;
- Other current lung disease (interstitial lung disease, idiopathic pulmonary fibrosis, asthma);
- IV drug use within the last year;
- History of lung surgery to remove part of the lung;
- Known bullae or advanced destructive emphysema in more than 1/3 of the lungs;
- Treatment for cancer (systemic therapy or surgical/radiation within the thorax) in the last 12 months;
- Known diagnosis of pulmonary hypertension;
- Known systolic heart failure (RV or LV EF < 40%);
- Acute or chronic renal insufficiency (estimated glomerular filtration rate [GFR] <60 mL/min/1.73 m2 or self-report). GFR will be calculated using the CKD-EPI equation;
- Current or planned pregnancy in the next year;
- Regular marijuana smoking;
- Exacerbation of respiratory symptoms within the previous 6 weeks, such as that requiring hospitalization, oral prednisone or antibiotics to control symptoms, or longer and not yet returned to baseline; and
- Chest, abdominal or eye surgery, or a heart attack or stroke, within the last 3 months.
Where it is running
- Brigham and Women's Hospital — Boston, Massachusetts, United States
Full record on ClinicalTrials.gov
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