Precision Medicine for Stem Cell Transplantation

Recruiting now

Conditions studied: Haematopoietic Stem Cell Transplantation

In brief

A study of patients undergoing haematopoietic stem cell transplantation, a procedure in which patients are infused with stem cells from a donor, resulting in a new immune system that eliminates cancer or replaces diseased bone marrow. This study aims to develop new blood tests that predict the onset of acute graft-versus-host disease (aGvHD) and leukaemia relapse, two life-threatening complications that frequently limit the success of treatment. Predictive tests would allow doctors to individualise prophylaxis and intervene early to abort complications before they develop. The study will also create a large collection of clinically annotated blood samples from 300 transplant recipients to support future research and provide a resource to the transplant research community.

Key facts

Study ID

NCT05567289

Run by

University of Manchester

People needed

300

Starts

2023-06-06

Expected to finish

2028-08-01

Last updated by the study team

2025-04-03

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Any recipient of allogeneic haematopoietic stem cell transplantation (HSCT)
• Children/infants may participate, there is no age restriction
• Patients participating in other clinical trials remain eligible

You may not qualify if…

• Weight <5kg
• Recipients of autologous stem cell transplants

Where it is running

• Manchester Royal Infirmary — Manchester, United Kingdom (enrolling)
• Royal Manchester Children's Hospital — Manchester, United Kingdom (enrolling)
• The Christie NHS Foundation Trust — Manchester, United Kingdom (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.