Physiology of Long COVID-19 and the Impact of Cardiopulmonary Rehabilitation on Quality-of-Life and Functional Capacity

Recruiting now · Not applicable

Conditions studied: Post-acute Sequelae of SARS-CoV-2 Infection

In brief

The primary objectives of this study are to determine whether exercise training is an effective strategy for treatment of Long COVID and characterize the cardiorespiratory and autonomic physiology in these patients to precisely characterize mechanisms contributing to this syndrome.

Key facts

Study ID

NCT05566483

Run by

University of Colorado, Denver

People needed

30

Starts

2023-03-01

Expected to finish

2027-10-31

Last updated by the study team

2025-12-04

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Adults ≥18 years with documented history of COVID-19 infection and symptoms consistent with Long COVID lasting >12 weeks after diagnosis.

You may not qualify if…

• History of cardiovascular/pulmonary disease prior to infection
• COVID-related myocardial injury such as evidence of myocarditis
• Deep vein thrombosis/pulmonary embolism following COVID-19 infection
• Exercise intolerance resulting from conditions that are not related to cardiorespiratory or autonomic factors (e.g. osteoarthritis or other musculoskeletal diseases);
• Dependency of supplemental oxygen following COVID infection due to cardiovascular and/or pulmonary complications following acute COVID infection

Where it is running

• University of Colorado Hospital — Aurora, Colorado, United States (enrolling)

Full record on ClinicalTrials.gov

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