Mode Of Ventilation During Critical IllnEss Pilot Trial

Completed · Not applicable

Conditions studied: Respiratory Failure

In brief

Landmark trials in critical care have demonstrated that, among critically ill adults receiving invasive mechanical ventilation, the use of low tidal volumes and low airway pressures prevents lung injury and improves patient outcomes. Limited evidence, however, informs the best method of mechanical ventilation to achieve these targets. To provide mechanical ventilation, clinicians must choose between modes of ventilation that directly control tidal volumes ("volume control"), modes that directly control the inspiratory airway pressure ("pressure control"), and modes that are hybrids ("adaptive pressure control"). Whether the choice of the mode used to target low tidal volumes and low inspiratory plateau pressures affects clinical outcomes for critically ill adults receiving mechanical ventilation is unknown. All three modes of mechanical ventilation are commonly used in clinical practice. A large, multicenter randomized trial comparing available modes of mechanical ventilation is needed to understand the effect of each mode on clinical outcomes. The investigators propose a 9-month cluster-randomized cluster-crossover pilot trial evaluating the feasibility of comparing three modes (volume control, pressure control, and adaptive pressure control) for mechanically ventilated ICU patients with regard to the outcome of days alive and free of invasive mechanical ventilation.

Key facts

Study ID

NCT05563779

Run by

Vanderbilt University Medical Center

People needed

566

Starts

2022-11-01

Expected to finish

2023-08-28

Last updated by the study team

2026-02-23

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥ 18 years
• Receiving mechanical ventilation through an endotracheal tube or tracheostomy
• Admitted to the study ICU

You may not qualify if…

• Patient is pregnant
• Patient is a prisoner
• Patient receiving invasive mechanical ventilation at place of residence prior to hospital admission
• Patient receiving extracorporeal membrane oxygenation at the time of admission to the study ICU

Where it is running

• Vanderbilt University Medical Center — Nashville, Tennessee, United States

Full record on ClinicalTrials.gov

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