Confirming the Effectiveness of Online Guided Self-Help Family-Based Treatment for Adolescent Anorexia Nervosa

Recruiting now · Not applicable

Conditions studied: Anorexia Nervosa

In brief

With an incidence rate of about 1%, Anorexia Nervosa (AN) is a serious mental disorder associated with high mortality, morbidity, and cost. AN in youth is more responsive to early treatment but becomes highly resistant once it has taken an enduring course. The first-line treatment for adolescents with AN is Family Based Treatment (FBT). While FBT can be delivered using videoconferencing (FBT-V), therapists' limited availability hampers scalability. Guided self-help (GSH) versions of efficacious treatments have been used to scale and increase access to care. The main aim of this proposed comparative effectiveness study is to confirm that clinical improvements in GSH-FBT are achieved with greater efficiency than FBT-V in generalizable clinical settings.

Key facts

Study ID

NCT05563649

Run by

Stanford University

People needed

200

Starts

2023-03-17

Expected to finish

2027-10-01

Last updated by the study team

2025-06-26

Who can join

Age: 12 and older, up to 18. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Participants are 12-18 years of age
• Participants live with a family (some families may contain only one parent)
• Family members fluently speak and read English and have access to a computer with internet
• Participants meet DSM-5 criteria for AN (both subtypes)
• EBW above 75%
• Participants are medically stable for outpatient treatment according to the recommended thresholds of the American Academy of Pediatrics and the Society of Adolescent Medicine
• Participants are not engaged in another individual or family-based psychotherapy trial during the duration of treatment sessions in the study.
• Medications for comorbid psychiatric disorders are OK; randomization will balance groups through tracking.

You may not qualify if…

• Current psychotic illness or intellectual disability or other mental illnesses that would prohibit the use of psychotherapy; current dependence on drugs or alcohol; physical conditions (e.g. diabetes mellitus, pregnancy) known to influence eating or weight; previous FBT; and inability of the participant and/or family to speak and understand English.

Where it is running

• Stanford University — Stanford, California, United States (enrolling)
• McMaster University — Hamilton, Ontario, Canada (enrolling)

Full record on ClinicalTrials.gov

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