Micro-UltraSound In Cancer - Active Surveillance

Recruiting now · Not applicable

Conditions studied: Prostate Cancer

In brief

This study will compare the two imaging modalities (MRI and micro-ultrasound) during Active Surveillance of prostate cancer (PCa). Progression to clinically significant PCa will be assessed by first taking micro-US targeted samples (while blinded to MRI results), followed by MRI targeted samples, finishing with 12 systematic biopsy cores. The primary goal is to compare microUS to MRI for the detection of ≥GG2 PCa at confirmatory biopsy. This study will also collect blood samples from participants to be used for future biomarker studies.

Key facts

Study ID

NCT05558241

Run by

University of Alberta

People needed

210

Starts

2022-11-30

Expected to finish

2033-07-30

Last updated by the study team

2026-06-25

Who can join

Age: 18 and older. Sex: male. Healthy volunteers: not accepted.

You may qualify if…

• Adult men with Gleason Grade Group 1 prostate cancer managed by active surveillance who require a confirmatory prostate biopsy

You may not qualify if…

• Men who cannot undergo a prostate MRI
• Men who cannot undergo a prostate biopsy

Where it is running

• University of California Los Angeles, Department of Urology — Los Angeles, California, United States (enrolling)
• Kipnes Urology Centre - Kaye Edmonton Clinic — Edmonton, Alberta, Canada (enrolling)
• University of British Columbia — Vancouver, Alberta, Canada (enrolling)
• CIUSSS du Nord-de-L'Ile-De-Montreal — Montreal, Quebec, Canada (enrolling)
• University Hospital Centre Zagreb — Zagreb, Croatia (enrolling)
• Humanitas — Milan, Italy (enrolling)

Full record on ClinicalTrials.gov

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