Effects of Pallidal Deep Brain Stimulation Location on Motor Impairment in Parkinson's Disease

Recruiting now · Not applicable

Conditions studied: Parkinson's Disease

In brief

This protocol will characterize the effects of deep brain stimulation (DBS) location (both adverse and beneficial) on motor signs in people with Parkinson's disease (PD). This information can be used to inform future DBS protocols to tailor stimulation to the specific needs of a patient. If targeted dorsal GP stimulation is shown to significantly improve motor features that are typically resistant to dopamine replacement therapy, these experiments will likely have major impact on clinical practice by providing a potential strategy to these medically intractable symptoms.

Key facts

Study ID

NCT05557864

Run by

University of Minnesota

People needed

24

Starts

2016-08-25

Expected to finish

2026-12-31

Last updated by the study team

2026-01-26

Who can join

Age: 21 and older, up to 89. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• diagnosis of idiopathic PD
• have undergone neurosurgery to implant deep brain stimulators in the globus pallidus (GP DBS) or subthalamic nucleus (STN)
• Existing 7T brain imagery

You may not qualify if…

• history of musculoskeletal disorders that significantly affect movement of the upper or lower limbs
• other significant neurological disorder
• history of dementia or cognitive impairment as found with UBACC (or MacCAT-CR)
• post-operative complications or adverse effects

Where it is running

• University Of Minnesota — Minneapolis, Minnesota, United States (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.