Therapeutic Mechanisms of Epidural Spinal Cord Stimulation

Recruiting now · Not applicable

Conditions studied: Blood Pressure, Low Back Pain, Hypertension

In brief

The purpose of this study in patients undergoing routine care epidural spinal cord stimulation (SCS) is to determine 1) whether SCS reduces arterial blood pressure (BP) in patients which chronic low back pain and hypertension, 2) whether higher baseline BP (i.e., hypertension) predicts reductions in pain following SCS, and finally 3) whether different SCS waveforms elicits stimulus-evoked compound action potentials (ECAPs) in spinal cord and at the cortex (electroencephalography, and magnetoenchphalography).

Key facts

Study ID

NCT05556902

Run by

University of Alabama at Birmingham

People needed

80

Starts

2022-08-02

Expected to finish

2030-05-01

Last updated by the study team

2025-08-28

Who can join

Age: 18 and older, up to 89. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male or Female, age 18-89
• Chronic pain for more than 3 months
• Willing to visit a research lab
• Willing to undergo a blood draw
• Able to provide written informed consent

You may not qualify if…

• History of neurological disease (e.g., dementias, Parkinson's)
• History of stroke
• Current diagnosis of cancer
• Subject is unwilling or unable to comply with the protocol

Where it is running

• University of Alabama at Birmingham — Birmingham, Alabama, United States (enrolling)

Full record on ClinicalTrials.gov

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