Global Blood-Brain Barrier Disruption and Post-Stroke Cognitive Decline

Recruiting now

Conditions studied: Ischemic Stroke

In brief

The goal of this study is to gain a better understanding of why some individuals who have suffered a stroke experience post-stroke cognitive decline. Specifically this study is testing whether global disruption of the blood-brain barrier detected at the time of the stroke is informative about the risk of post-stroke cognitive decline over the next 3 years.

Key facts

Study ID

NCT05556395

Run by

Johns Hopkins University

People needed

150

Starts

2022-04-01

Expected to finish

2027-04-01

Last updated by the study team

2025-09-29

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Acute ischemic stroke demonstrated on an MRI scan that includes perfusion imaging with an exogenous contrast agent

You may not qualify if…

• Inability to perform telephone-based cognitive assessments

Where it is running

• Johns Hopkins Hospital — Baltimore, Maryland, United States (enrolling)

Full record on ClinicalTrials.gov

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