Genetic Characterization of Cardiomyopathies (POLICARDIOMIO2021)
Recruiting now
Conditions studied: Cardiomyopathies
In brief
Cardiomyopathy refers to a diverse group of myocardial diseases with multiple causes. In 1995, the World Health Organization classified cardiomyopathies into hypertrophic, dilated, restrictive, and mixed type. This classification is based on the pathophysiology of the disease. However, with rapid evolution of molecular genetics in cardiology, the American Heart Association in 2006 has classified cardiomyopathies into two major groups based on predominant organ involvement and etiology; Primary cardiomyopathies are those solely or predominantly confined to heart muscle and are relatively few in number. Secondary cardiomyopathies show pathologic myocardial involvement as part of a large number and variety of generalized systemic (multiorgan) disorders.Current evidence supports the use of genetic testing in clinical practice to improve risk stratification for clinically affected patients and their at-risk relatives for cardiomyopathies.
Key facts
- Study ID
- NCT05556369
- Run by
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
- People needed
- 288
- Starts
- 2021-09-01
- Expected to finish
- 2026-09-01
- Last updated by the study team
- 2024-04-22
Who can join
Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Presence of structural cardiomyopathy
- First degree relatives for cardiomyopathy
You may not qualify if…
- Age > 80
- Presence of sufficient conditions to explain the clinical condition of cardiomyopathy
- Peripartum cardiomyopathy
Where it is running
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico — Milan, Lombardy, Italy (enrolling)
Full record on ClinicalTrials.gov
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