Safety and Efficacy of ALXN1720 in Adults With Generalized Myasthenia Gravis

Running, not enrolling · Phase 3 · Has a placebo group

Conditions studied: Generalized Myasthenia Gravis

In brief

The purpose of this study is to evaluate the safety and efficacy of ALXN1720 for the treatment of generalized MG (gMG) in adults with autoantibodies against acetylcholine receptor (AChR).

Key facts

Study ID

NCT05556096

Run by

Alexion Pharmaceuticals, Inc.

People needed

260

Starts

2022-11-21

Expected to finish

2027-08-31

Last updated by the study team

2026-06-17

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of MG with generalized muscle weakness meeting the clinical criteria defined by Myasthenia Gravis Foundation of America (MGFA) Class II, III or IV
• Positive serological test for autoantibodies against AChR

You may not qualify if…

• History of thymectomy, or any other thymic surgery within 12 months prior to Screening
• Untreated thymic malignancy, carcinoma, or thymoma
• History of Neisseria meningitidis infection
• Pregnancy, breastfeeding, or intention to conceive during the course of the study

Where it is running

• Research Site — Düsseldorf, Germany
• Research Site — München, Germany
• Research Site — Würzburg, Germany
• Research Site — Hadera, Israel
• Research Site — Haifa, Israel
• Research Site — Petah Tikva, Israel
• Research Site — Bergamo, Italy
• Research Site — Brescia, Italy
• Research Site — Florence, Italy
• Research Site — Milan, Italy
• Research Site — Naples, Italy
• Research Site — Palermo, Italy
• Research Site — Pisa, Italy
• Research Site — Roma, Italy
• Research Site — Rome, Italy
• Research Site — Chiba, Japan
• Research Site — Fukushima, Japan
• Research Site — Higashimatsuyama-shi, Japan
• Research Site — Isehara-shi, Japan
• Research Site — Itabashi-ku, Japan
• Research Site — Kawasaki-shi, Japan
• Research Site — Morioka, Japan
• Research Site — Nagasaki, Japan
• Research Site — Nagoya, Japan
• Research Site — Berlin, Germany

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.