Datopotamab Deruxtecan (Dato-DXd) and Pembrolizumab With or Without Platinum Chemotherapy in 1L Non-Small Cell Lung Cancer (TROPION-Lung07)
Running, not enrolling · Phase 3
Conditions studied: Metastatic Non Small Cell Lung Cancer
In brief
This study is designed to assess the efficacy and safety of datopotamab deruxtecan (Dato-DXd) in combination with pembrolizumab versus pembrolizumab in combination with pemetrexed and platinum chemotherapy in participants with no prior therapy for advanced or metastatic non-squamous non-small cell lung cancer (NSCLC).
Key facts
- Study ID
- NCT05555732
- Run by
- Daiichi Sankyo
- People needed
- 1170
- Starts
- 2023-01-11
- Expected to finish
- 2031-05-11
- Last updated by the study team
- 2026-06-23
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Southern Cancer Center Pc — Daphne, Alabama, United States
- Ironwood Cancer and Research Centers — Chandler, Arizona, United States
- Arizona Oncology Associates, Pc - Nahoa — Prescott Valley, Arizona, United States
- Hoag Memorial Hospital Prebyterian — Newport Beach, California, United States
- Compassionate Cancer Care Medical Group — Riverside, California, United States
- Sansum Clinic — Santa Barbara, California, United States
- Ronald Reagan UCLA Medical Center — Santa Monica, California, United States
- UCHealth Memorial Hospital — Colorado Springs, Colorado, United States
- Florida Cancer Specialists - South — Fort Myers, Florida, United States
- Cancer Specialist of North Florida — Jacksonville, Florida, United States
- Cancer Care Centers of Brevard, Inc. — Palm Bay, Florida, United States
- Woodlands Medical Specialists, Pa — Pensacola, Florida, United States
- Florida Cancer Specialists-North — St. Petersburg, Florida, United States
- Emory University - Winship Cancer Institute Wci — Atlanta, Georgia, United States
- Illinois Cancer Specialists — Niles, Illinois, United States
- American Oncology Partners of Maryland — Bethesda, Maryland, United States
- Maryland Oncology Heamtology P.A. — Columbia, Maryland, United States
- Beth Israel Deaconess Medical Center — Boston, Massachusetts, United States
- Dana Farber Cancer Institute; Inv Drg Svc Pharm — Boston, Massachusetts, United States
- Dana Farber Cancer Institute At St. Elizabeth'S Medical Center — Brighton, Massachusetts, United States
- Dana Farber Brigham Cancer Center — Foxborough, Massachusetts, United States
- Dana Farber At Milford Regional Cancer Center — Milford, Massachusetts, United States
- Dana Farber/Bwcc in Affiliation With South Shore Hospital — South Weymouth, Massachusetts, United States
- Astera Cancer Care — East Brunswick, New Jersey, United States
- Onco Clinic Consult Sa — Craiova, Romania
Full record on ClinicalTrials.gov
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