Evaluation of Inflammatory Markers in ph Negative Myeloproliferative Neoplasms: Impact on Outcome and Response to Therapy. Multicenter Retro-prospective Observational Study. The INFLA-ME (INFLAmmation in Myeloproliferative Disease) Study.
Recruiting now
Conditions studied: Myeloproliferative Disease, Inflammatory Markers
In brief
This study aims to observe inflammatory biomarkers and their trend over the history of the disease in patients suffering from MPN Ph negative; it also wants to identify any correlations between the aforementioned biomarkers and disease outcomes, considering first of all the occurrence of thrombo-haemorrhagic events and the evolution in the accelerated / blast phase of the disease, shedding light on new tools that can potentially guarantee a prompt and better risk stratification
Key facts
- Study ID
- NCT05553873
- Run by
- University of Milano Bicocca
- People needed
- 500
- Starts
- 2022-09-08
- Expected to finish
- 2026-12-01
- Last updated by the study team
- 2024-01-02
Who can join
Age: 18 and older, up to 99. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age ≥ 18 years at the time of diagnosis of MPN Ph negative
- Diagnosis of PV, ET, PMF or post PV and post ET MF, according to current WHO or IWG-MRT criteria (diagnosis since 2000)
- Obtaining informed consent
You may not qualify if…
- Life expectancy of less than 6 months
- Accelerated phase myelofibrosis or MPN with signs of leukemic evolution
Where it is running
- Azienda Ospedaliera Universitaria Consorziale Policlinico — Bari, Italy (enrolling)
- Policlinico Sant'Orsola Malpighi — Bologna, Italy (enrolling)
- ASST Spedali Civili di Brescia — Brescia, Italy (enrolling)
- Policlinico Vittorio Emanuele — Catania, Italy (enrolling)
- Ospedale Universitario Federico II — Naples, Italy (enrolling)
- Policlinico Umberto I, Università La Sapienza — Roma, Italy (enrolling)
- Azienda Ospedaliera Universitaria Città della Salute e delle Scienza — Torino, Italy (enrolling)
- Ospedale San Luigi di Orbassano - Ospedale Mauriziano — Torino, Italy (enrolling)
- Azienda Ospedaliera Universitaria Friuli Centrale — Udine, Italy (enrolling)
- Azienda Ospedaliera Universitaria Integrata — Verona, Italy (enrolling)
- Ospedale Belcolle — Viterbo, Italy (enrolling)
Full record on ClinicalTrials.gov
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