Safest Choice of Antihypertensive Regimen for Postpartum Hypertension

Recruiting now · Phase 3

Conditions studied: Postpartum Complication, Maternal Hypertension, High Blood Pressure

In brief

The purpose of this investigator-initiated randomized control trial is to determine whether oral Nifedipine versus oral Labetalol is superior in controlling high blood pressures in the postpartum period.

Key facts

Study ID

NCT05551104

Run by

Loma Linda University

People needed

500

Starts

2023-05-08

Expected to finish

2027-12-01

Last updated by the study team

2026-02-04

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Female
• Women who develop postpartum hypertension* after delivery of the placenta or chronic hypertensive postpartum women who require medication for blood pressure control.
• Postpartum hypertension requiring treatment are defined as systolic blood pressure greater than or equal to 140mmHg or diastolic blood pressure greater than or equal to 90mmHg on at least 2 occasions at least 4 hours apart, or systolic blood pressure greater than or equal to 160mmHg or diastolic blood pressure greater than 110mmHg sustained for more than 15 minutes.

You may not qualify if…

• History of moderate persistent asthma, coronary artery disease, heart failure, AV heart block, pulmonary edema
• Contraindication to either Nifedipine or Labetalol
• HR <60 or >110
• Native language other than English or Spanish

Where it is running

• Loma Linda University Health — Loma Linda, California, United States (enrolling)

Full record on ClinicalTrials.gov

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