Multi-Center Molecular Diagnosis and Host Response of Respiratory Viral Infections in Pediatric Transplant Recipients
Recruiting now
Conditions studied: Hematopoietic Cell Transplant, Solid Organ Transplant, Respiratory Viral Infection
In brief
The participants are being asked to take part in this clinical trial, a type of research study, because the participants are scheduled to receive or have recently received a hematopoietic cell transplant (HCT) or a solid organ transplant (SOT). Primary Objective To determine if pre-transplant screening for respiratory viral load predicts RVI within 1- year post-transplant among survivors. Secondary Objectives: * To develop and validate a classifier based on pre-transplant immunological profile predictive of developing an acute respiratory viral infection (aRVI), with RSV/PIV3/HMPV/SARS-CoV-2 through one-year post-transplant among survivors. * To develop and validate a classifier based on Day +100 post-transplant immunological profiles predictive of developing an acute respiratory viral infection (aRVI),with RSV/PIV3/HMPV/SARS-CoV-2 through one-year post-transplant among survivors .
Key facts
- Study ID
- NCT05550298
- Run by
- Arkansas Children's Hospital Research Institute
- People needed
- 2000
- Starts
- 2022-12-13
- Expected to finish
- 2029-08-01
- Last updated by the study team
- 2025-10-02
Who can join
Age: any, up to 18. Sex: any. Healthy volunteers: not accepted.
You may not qualify if…
- Recipient Exclusion Criteria
- None
- Donor Exclusion Criteria
- Is not an HCT donor for a participant enrolled on the VIPER study.
- Not available to provide pre-transplant research blood sample.
Where it is running
- University of Alabama at Birmingham's (UAB) — Birmingham, Alabama, United States (enrolling)
- Arkansas Children's Hospital — Little Rock, Arkansas, United States (enrolling)
- Children's National Medical — Washington D.C., District of Columbia, United States (enrolling)
- University if Miami — Miami, Florida, United States (enrolling)
- Emory and Children's Healthcare of Atlanta — Atlanta, Georgia, United States (enrolling)
- University of Chicago Medicine Comer Children's Hospital — Chicago, Illinois, United States (enrolling)
- University of Louisville — Louisville, Kentucky, United States (enrolling)
- Boston Children's Hospital — Boston, Massachusetts, United States (enrolling)
- C.S. Mott Children's Hospital — Ann Arbor, Michigan, United States (enrolling)
- Children's Hospital of Michigan — Detroit, Michigan, United States (enrolling)
- University of Minnesota — Minneapolis, Minnesota, United States (enrolling)
- Washington University — St Louis, Missouri, United States (enrolling)
- University of Nebraska Medical Center — Omaha, Nebraska, United States (enrolling)
- The Children's Hospital at Montefiore — The Bronx, New York, United States (enrolling)
- Cincinnati Children's Hospital Medical Center — Cincinnati, Ohio, United States (enrolling)
- Nationwide Children's Hospital — Columbus, Ohio, United States (enrolling)
- UPMC — Pittsburgh, Pennsylvania, United States (enrolling)
- Medical University of South Carolina — Charleston, South Carolina, United States (enrolling)
- Le Bonheur Children's Hospital — Memphis, Tennessee, United States (enrolling)
- St. Jude Children's Research Hospital — Memphis, Tennessee, United States (enrolling)
- UT Le Bonheur — Memphis, Tennessee, United States (enrolling)
- Cook Children's — Fort Worth, Texas, United States (enrolling)
- Baylor College of Medicine — Houston, Texas, United States (enrolling)
- MD Anderson Center Center — Houston, Texas, United States (enrolling)
- UTHealth Houston — Houston, Texas, United States (enrolling)
Full record on ClinicalTrials.gov
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