Open-Label Study of AXS-07 for the Acute Treatment of Migraine in Adults With a Prior Inadequate Response to an Oral CGRP Inhibitor (EMERGE)

Completed · Phase 3

Conditions studied: Migraine

In brief

This is a multicenter, open-label trial to evaluate the efficacy and safety of AXS-07 in subjects with migraine attacks and prior inadequate response to oral CGRP inhibitors.

Key facts

Study ID

NCT05550207

Run by

Axsome Therapeutics, Inc.

People needed

100

Starts

2022-08-31

Expected to finish

2024-11-27

Last updated by the study team

2025-12-02

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Has an established diagnosis of migraine with or without aura
• Has experienced an inadequate response to oral CGRP inhibitors for the acute treatment of migraine

You may not qualify if…

• Pregnant, breastfeeding, or planning to become pregnant during the study
• Has previously received any investigational drug or device or investigational therapy within 30 days before Screening

Where it is running

• Clinical Research Site — Colton, California, United States
• Clinical Research Site — Fullerton, California, United States
• Clinical Research Site — La Jolla, California, United States
• Clinical Research Site — Los Angeles, California, United States
• Clinical Research Site — Sherman Oaks, California, United States
• Clinical Research Site — Stamford, Connecticut, United States
• Clinical Research Site — DeLand, Florida, United States
• Clinical Research Site — Hallandale, Florida, United States
• Clinical Research Site — Hollywood, Florida, United States
• Clinical Research Site — Miami, Florida, United States
• Clinical Research Site — Ormond Beach, Florida, United States
• Clinical Research Site — Oviedo, Florida, United States
• Clinical Research Site — Pensacola, Florida, United States
• Clinical Research Site — Winter Park, Florida, United States
• Clinical Research Site — Stockbridge, Georgia, United States
• Clinical Research Site — Avon, Indiana, United States
• Clinical Research Site — Boston, Massachusetts, United States
• Clinical Research Site — North Dartmouth, Massachusetts, United States
• Clinical Research Site — Las Vegas, Nevada, United States
• Clinical Research Site — Albuquerque, New Mexico, United States
• Clinical Research Site — The Bronx, New York, United States
• Clinical Research Site — Williamsville, New York, United States
• Clinical Research Site — Philadelphia, Pennsylvania, United States
• Clinical Research Site — Charleston, South Carolina, United States
• Clinical Research Site — Knoxville, Tennessee, United States

Full record on ClinicalTrials.gov

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