Pharmacogenetic-guided Choice of Post-surgery Analgesics
Completed · Not applicable
Conditions studied: Acute Pain, Post Operative Pain
In brief
Pharmacogenomics (PGx) is the study of how genes affect a person's response to drugs. PGx testing for certain genes can help predict the risk of side effects or therapeutic failure from analgesics. Testing is not regularly performed in clinical practice due to long wait times for results and challenges with integrating test results in the electronic health record. Investigators leading this study hope to find out if providing surgeons with the ability to order a PGx test and electronically receive results with dosing recommendations will increase the use of these tests to guide analgesic choice and improve patient outcomes. This is a prospective, two-arm randomized implementation study. Eligible participants will be randomly assigned to receive genotype-guided analgesic selection (intervention arm) or usual care (control arm). Both cohorts will undergo pharmacogenetic testing at the time of consenting. The investigators will primarily measure the feasibility of using this test to guide analgesic selection.
Key facts
- Study ID
- NCT05548660
- Run by
- University of Pennsylvania
- People needed
- 112
- Starts
- 2022-10-13
- Expected to finish
- 2025-02-01
- Last updated by the study team
- 2026-04-01
Who can join
Age: 18 and older. Sex: female. Healthy volunteers: not accepted.
You may qualify if…
- Able and willing to provide informed consent
- Assigned female at birth and aged 18 years or older at the time of study initiation
- Major gynecologic surgery indicated and planned for hysterectomy, myomectomy, exploratory laparotomy, and open abdominal surgery
- Willing to provide a buccal swab for PGx testing and comply with all study-related procedures
You may not qualify if…
- Receiving chronic opioid therapy defined as ≥ 3 consecutive months of 1-month prescriptions for an opioid
- Pregnancy
- Breastfeeding
- Treating physician does not want subject to participate
Where it is running
- University of Pennsylvania — Philadelphia, Pennsylvania, United States
Full record on ClinicalTrials.gov
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