Clinical and Diagnostic Features of Endocarditis

Recruiting now

Conditions studied: Endocarditis

In brief

The burden of endocarditis has changed in the last years due to an increase in percutaneous valve procedures offered to a more fragile, and old population. Therefore an update in epidemiology data is necessary. The Observational prospective multicenter study to characterize the cLinical ANd DiagnoStiC feAtures of endocarditis in the contemPorary Era, (ENDO-LANDSCAPE study) is an observational, multicenter and international study. The study has two arms: retrospective and prospective. The retrospective arm will involve collecting data from patients discharged with a diagnosis of endocarditis between 2016 and 2022. The data obtained in the retrospective arm of the study will be utilized in a power calculation to determine the sample size for the prospective arm of the study. In the prospective phase in every participating center, all patients referred for echocardiography to assess for endocarditis and those with established endocarditis independent of the screened request will be eligible. Patients will then be stratified according to the presence or abscence of endocarditis. Those with an established diagnosis of endocarditis will be prospectively followed for outcomes.

Key facts

Study ID

NCT05547607

Run by

University Hospital of Ferrara

People needed

500

Starts

2022-09-09

Expected to finish

2028-06-30

Last updated by the study team

2026-05-01

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients above the age of 18 years.
• all consecutive patients referred for echocardiography (transthoracic or transesophageal approach) to exclude endocarditis.
• patients with a diagnosis of endocarditis on echocardiography independently by the request for the exam.

You may not qualify if…

• patient's refusal.

Where it is running

• University Hospital of Ferrara — Cona, Ferrara, Italy (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.