Study of Iadademstat and Gilteritinib in Patients With R/R AML With FMS-like Tyrosine Kinase Mutation (FLT3 Mut+)
Status unconfirmed · Phase 1
Conditions studied: Acute Myeloid Leukemia, in Relapse, Acute Myeloid Leukemia Refractory
In brief
Iadademstat is being studied as a treatment for subjects with Relapsed or Refractory Acute Myeloid Leukemia (R/R AML) with FMS-like tyrosine kinase mutation (FLT3 mut+). During the trial, iadademstat will be given in combination with gilteritinib, a drug that is already approved to treat patients with FLT3-mutated R/R AML.
Key facts
- Study ID
- NCT05546580
- Run by
- Oryzon Genomics S.A.
- People needed
- 50
- Starts
- 2022-11-14
- Expected to finish
- 2025-11-30
- Last updated by the study team
- 2024-07-29
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Banner MD Anderson Cancer Center — Gilbert, Arizona, United States (enrolling)
- The University of Arizona Cancer Center - North Campus — Tucson, Arizona, United States (enrolling)
- Sylvester Comprehensive Cancer Center — Miami, Florida, United States (enrolling)
- Miami Cancer Institute — Miami, Florida, United States (enrolling)
- The John Hopkins University School of Medicine — Baltimore, Maryland, United States (enrolling)
- Massachusetts General Hospital (MGH) — Boston, Massachusetts, United States (enrolling)
- Rutgers, The State University — Piscataway, New Jersey, United States (enrolling)
- Icahn School of Medicine at Mount Sinai and Mount Sinai Hospital — New York, New York, United States (enrolling)
- Duke University Medical Center — Durham, North Carolina, United States (enrolling)
- Oregon Health & Science University — Portland, Oregon, United States (enrolling)
- Sarah Cannon Research Institute, LLC — Nashville, Tennessee, United States (enrolling)
- West Virginia University — Morgantown, West Virginia, United States (enrolling)
- Froedtert Hospital & The Medical College of Wisconsin — Milwaukee, Wisconsin, United States (enrolling)
Full record on ClinicalTrials.gov
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