Assessment of Methadone and Buprenorphine in Interstitial Fluid
Completed
Conditions studied: Opioid Use Disorder
In brief
The purpose of this research is to determine if common medications for opioid use disorder (i.e., buprenorphine/naloxone, buprenorphine, methadone) and their metabolites (norbuprenorphine \[a metabolite of buprenorphine\], buprenorphine-3-glucuronide \[B3G; a metabolite in buprenorphine\], ethylidene dimethyl diphenyl pyrrolidine \[EDDP; a metabolite of methadone\]) can be detected in the dermal interstitial fluid (i.e., fluid extracted from the surface of the skin). Additional subjects who are not prescribed or taking any of these medications will be included in this study to act as a comparison group
Key facts
- Study ID
- NCT05546229
- Run by
- Cari Health Inc.
- People needed
- 11
- Starts
- 2022-09-14
- Expected to finish
- 2022-10-31
- Last updated by the study team
- 2023-06-28
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Age 18-65.
- A prescription for buprenorphine at dose ≥ 16 mg/4mg, a prescription for buprenorphine/naloxone at dose ≥ 16 mg/4mg, a prescription for methadone at dose ≥ 60mg, or part of the control group.
- Taken buprenorphine, buprenorphine/naloxone, or methadone as prescribed in the last 7 days, or part of the control group
You may not qualify if…
- A condition preventing or complicating ISF collection. Conditions may include dermatological (skin) condition, immunodeficiency, recent blood donation, anemia, cancer, congestive heart failure, HIV, Hepatitis C [HCV], or tuberculosis [TB].
- Any active severe depression (e.g., suicidal ideation) or mania symptoms.
- Lactation, pregnancy, or intending to become pregnant during the course of the study.
- Alcohol use in the past 7 days.
- Illicit substance use in past 7 days (e.g., heroin, methamphetamines).
- Under a conservatorship.
Where it is running
- Synergy San Diego — Lemon Grove, California, United States
Full record on ClinicalTrials.gov
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