Chardonnay Marc and Vascular Response

Recruiting now · Not applicable

Conditions studied: Cardiovascular Diseases, Vascular Dilation, Oxidative Stress

In brief

This study aims to obtain data on the potential influence of Vine to Bar product(s) containing Chardonnay marc on cardiometabolic health. These initial studies will inform the design and timing of data collection for future dietary intervention trials that will examine the influence of Chardonnay marc intake on outcomes/biomarkers of both cardiometabolic health and the gut microbiome. This includes collecting data on the potential differences in response to the products based on the unique food matrix for each of the products that will be tested. Moreover, as there is a paucity of data on the influence of cocoa flavanol intake on vascular function beyond 4 hours post intake, the response of the selected outcomes will be assessed after 6 hours of flavanol intake. This is a time point that captures the increased circulating presence of microbial derived flavanol metabolites.

Key facts

Study ID

NCT05545865

Run by

University of California, Davis

People needed

5

Starts

2022-09-01

Expected to finish

2026-08-24

Last updated by the study team

2026-02-18

Who can join

Age: 30 and older, up to 50. Sex: male. Healthy volunteers: accepted.

You may qualify if…

• Screening or Visit 1 Reactive Hyperemia Index (RHI; EndoPAT 2000) < 2.0
• Subject is willing and able to comply with the study protocols.
• Subject is willing to participate in all study procedures
• BMI 25.0 - 35 kg/m2

You may not qualify if…

• BMI ≥ 35 kg/m2
• Indivduals that weight less than a 110 lbs
• Donation of blood within the previous 30 days
• Visit 1 Reactive Hyperemia Index (RHI; EndoPAT 2000) ≥ 2.0
• 1 ug/ml and 3 ug/ml collagen screening maximal platelet aggregatory response of < 65%.
• Platelet counts < 150,000 / ul
• Anemia, which includes self report, or a screening hemoglobin and hematocrit that is less than the normal reference range or as diagnosed by study physician upon review of complete blood cell count reports.
• Dislike or allergy for nuts, cocoa or grape products
• Self-reported use of daily anticoagulation agents including aspirin, NSAIDs
• Vegan, Vegetarians, food faddists or those consuming a non-traditional diet
• Fruit consumption ≥ 3 cups/day
• Vegetable consumption ≥ 4 cups/day
• Nut intake ≥ 2 servings/ week
• Coffee/tea ≥ 3 cups/day
• Dark chocolate ≥ 3 oz/day
• Self-reported restriction of physical activity due to a chronic health condition
• Self-reported chronic/routine high intensity exercise
• Self-reported diabetes
• Blood pressure ≥ 140/90 mm Hg
• Self-reported renal or liver disease
• Self-reported heart disease, which includes cardiovascular events and stroke
• Peripheral artery disease, Raynaud's syndrome
• Inability to properly place or wear the PAT probes or abnormal measurements on pre- screening PAT
• Self-reported cancer within past 5 years
• Self-reported malabsorption

Where it is running

• Academic Surge, University of California, Davis — Davis, California, United States (enrolling)

Full record on ClinicalTrials.gov

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