Ketorolac Intravenous Regional Analgesia in Lower Limb Surgeries

Recruiting now · Not applicable

Conditions studied: Postoperative Pain, Acute

In brief

Tourniquet, a compressing device, otherwise its use in intravenous regional anesthesia, is commonly used in particular orthopedic surgeries. From the previous documented effectiveness and safety of intravenous (IV) administration of ketorolac in the circulatory-isolated limb as a part of intravenous regional anesthesia; we hypothesized that in orthopedic surgeries done with tourniquet, intravenous (IV) administration of ketorolac after tourniquet inflation, will act as intravenous regional analgesia. So, it will prolong the postoperative analgesic duration as a primary outcome.

Key facts

Study ID

NCT05543785

Run by

Mansoura University

People needed

76

Starts

2022-11-01

Expected to finish

2027-12-30

Last updated by the study team

2026-02-17

Who can join

Age: 19 and older, up to 60. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• American Society of Anesthesiologists physical status I or II
• Elective unilateral lower limb orthopedic surgery with tourniquet under spinal anesthesia

You may not qualify if…

• Pregnant females
• Body mass index ≥ 35 kg/m2
• Allergy to ketorolac
• Had renal, asthmatic, vascular (Raynaud's syndrome) disease, hematological anemias
• Had any history of gastrointestinal tract inflammation, bleeding, ulceration, or perforation besides
• Edema in the operated limb grade ≥ 3

Where it is running

• Mansoura University Hospitals — Al Mansurah, Egypt (enrolling)

Full record on ClinicalTrials.gov

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