Urinary Prostaglandin as a Potential Predictive Marker for Thiazide-induced Hyponatremia

Recruiting now

Conditions studied: Thiazide-induced Hyponatremia (TIH)

In brief

Thiazides and thiazide-like diuretics are one of the five major classes of antihypertensive drugs. This study is to investigate whether urinary PGE2 concentration at baseline (prior to thiazide initiation) is associated with the development of TIH within the first four weeks of treatment.

Key facts

Study ID

NCT05542056

Run by

University Hospital, Basel, Switzerland

People needed

232

Starts

2022-09-26

Expected to finish

2026-07-01

Last updated by the study team

2025-07-01

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Newly prescribed thiazide or thiazide-like diuretic
• ≥ 18 years of age
• Informed Consent as documented by signature

You may not qualify if…

• Intake of thiazide or thiazide-like diuretic in the preceding month
• Hyponatremia (plasma sodium <135 mmol/L) at baseline
• Acute infectious / inflammatory disease (CRP ≥ 20 mg/L [1, 11])
• Symptomatic urinary tract infection
• Chronic treatment with NSAID and / or NSAID intake 48 hours prior to urine sampling at visit 1 and 2 (intake of acetylsalicylic acid will be no exclusion criteria)
• End of life care, no informed consent or inability to follow the procedures of the study, e.g., due to language barriers, psychological disorders, dementia

Where it is running

• Hospital Universitario de Móstoles — Móstoles, Spain (enrolling)
• University Hospital Basel, Endocrinology, Diabetes and Metabolism — Basel, Switzerland (enrolling)
• Kantonsspital Baselland — Liestal, Switzerland (enrolling)

Full record on ClinicalTrials.gov

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