Use Muscadine Wine Nutraceuticals to Improve Brain Health, Cognition, and Mental Health

Paused · Not applicable · Has a placebo group

Conditions studied: Cognitive Performance, Memory, Mood, Anxiety

In brief

Previous studies have shown that polyphenol-rich foods can positively affect cognitive functions, memory, and mood in humans. We hypothesize that both acute and chronic intake of muscadine wine polyphenols will improve cognitive performance and mood through regulating the HPA axis, alleviating inflammation and oxidative stress, and/or inhibiting monoamine oxidase activities

Key facts

Study ID

NCT05541887

Run by

University of Florida

People needed

25

Starts

2023-08-30

Expected to finish

2028-12-31

Last updated by the study team

2026-08-10

Who can join

Age: 50 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy
• BMI (18.5-29.9)
• Body weight ≥110 pounds

You may not qualify if…

• Pregnancy
• Breast-feeding
• Smokers
• Diabetic
• Heavy drinkers
• Subjective but not clinically diagnosed cognitive impairment (Montreal cognitive assessment score <26),
• Inability to understand the cognitive function tasks
• Intake of medication that might influence the outcome of the study (e.g. psychostimulant)
• cannabis product user
• Clinically diagnosed mental illnesses
• Cardiovascular and neurological disorders
• Uncontrolled hypertension

Where it is running

• Food Science and human nutrition department at University of Florida — Gainesville, Florida, United States

Full record on ClinicalTrials.gov

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