Optimisation Strategy for Emergency Tracheal Intubation

Recruiting now · Not applicable

Conditions studied: Emergencies, Out-of-hospital Setting, Tracheal Intubation

In brief

This study has to objective to assess, in adults' patients needing tracheal intubation because of vital distress, the effect of a combined strategy to reduce intubation-related morbidity. This strategy will associate systematic use of rocuronium as paralyzing agent to facilitate tracheal intubation, bag face-mask ventilation before intubation and Gum Elastic Bougie (GEB) use.

Key facts

Study ID

NCT05539391

Run by

University Hospital, Bordeaux

People needed

1500

Starts

2023-01-14

Expected to finish

2026-09-01

Last updated by the study team

2025-09-24

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patient adult (≥ 18 years) presenting with vital distress requiring emergency tracheal intubation as assessed by the emergency physician in the out-of-hospital setting.
• Patient with all conditions (trauma, dyspnea, coma, overdoses, and shock) except those in cardiac arrest will be included.

You may not qualify if…

• Patient presenting of a contraindication to succinylcholine, and/or rocuronium, and/or sugammadex (rocunorium antagonist).
• Patient who have contraindication to bag face mask ventilation before intubation (ongoing emesis, hematemesis, or hemoptysis).
• Patient that are not members of a medical aid scheme (beneficiary or main member).
• Patient under specific protection measures: pregnant, parturient or nursing women; legal protection or deprived of liberty: patient under judicial protection, patient under guardianship/curatorship.

Where it is running

• CHU Toulouse - Hôpital Purpan — Toulouse, France (enrolling)
• CH Carnelle Portes de l'Oise — Beaumont-sur-Oise, France (enrolling)
• AP-HP - Hôpital Avicenne — Bobigny, France (enrolling)
• CHU de Bordeaux - Hôpital Pellegrin — Bordeaux, France (enrolling)
• CH de Pontoise René Dubos — Cergy-Pontoise, France (enrolling)
• AP-HP - Hôpital Henri Mondor — Créteil, France (enrolling)
• CHU Poitiers - Hôpital la Milétrie — Poitiers, France (enrolling)
• CHU de la Réunion - site Sud — Saint-Pierre, France (enrolling)
• CHU d'Angers — Angers, France (enrolling)
• GH Eaubonne Montmorency Hôpital Simone VEIL — Eaubonne, France (enrolling)
• AP-HP - Hôpital Raymond Poincaré — Garches, France (enrolling)
• CHU de Grenoble - Hôpital Nord La Tronche — La Tronche, France (enrolling)
• HCL - Hôpital Edouard Herriot — Lyon, France (enrolling)
• GH Sud Ile de France — Melun, France (enrolling)
• CHU de Montpellier Site Lapeyronie — Montpellier, France (enrolling)
• CHU de Nantes - Hôpital Hôtel Dieu — Nantes, France (enrolling)
• AP-HP - Hôpital Lariboisière — Paris, France (enrolling)
• AP-HP - Hôpital Pitié-Salpétrière — Paris, France (enrolling)
• AP-HP - Hôpital Necker — Paris, France (enrolling)
• CHU de Dijon — Dijon, France
• GH Sélestat Obernai — Sélestat, France
• CH de Versailles - Site André Mignot — Le Chesnay, France

Full record on ClinicalTrials.gov

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