A Study to Learn About the Study Medicine Called PF-07799544 as Monotherapy or in Combination in People With Advanced Solid Tumors
Recruiting now · Phase 1
Conditions studied: Melanoma, Glioma, Thyroid Cancer, Non-Small Cell Lung Cancer, Malignant Neoplasms, Brain Neoplasms, Advanced or Metastatic Solid Tumors, HGG, LGG, Low Grade Glioma, High Grade Glioma, Differentiated Thyroid Cancer, NSCLC (Non-small Cell Lung Cancer)
In brief
The purpose of this clinical trial is to learn the safety and effects of the study medicine (PF-07799544) alone or in combination as a potential cancer treatment for adults with advanced solid tumors. The study will be conducted in two parts: PF-07799544 as a single agent (Phase 1a) and PF-07799544 in combination with another study medicine called PF-07799933 (Phase 1b). Phase 1a is no longer open for enrollment. In Phase1b (noted as "this study"), we are seeking participants who have: * a solid tumor which is metastatic or recurrent (excluding colorectal cancer) * tumor with the mutation (abnormal gene) called "BRAF V600" * received required prior treatment for cancer per cohort assigned. All participants in this study will receive both study medicines. Both study medicines are tablets that are taken by mouth at home twice a day. Participants will receive study medicines until their cancer is no longer responding, unacceptable side effects, or 2 years. Participants may continue to receive study therapy beyond 2 years. We will examine the experiences of people receiving the study medicines. This will help us determine if the study medicines are safe and effective.
Key facts
- Study ID
- NCT05538130
- Run by
- Pfizer
- People needed
- 124
- Starts
- 2022-11-30
- Expected to finish
- 2029-06-18
- Last updated by the study team
- 2026-07-29
Who can join
Age: 16 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- NYU Langone Medical Center (Tisch Hospital) — New York, New York, United States (enrolling)
- Memorial Sloan Kettering Cancer Center 53rd street. — New York, New York, United States (enrolling)
- MSK Westchester. — Harrison, New York, United States (enrolling)
- NYU Langone Faculty Group Practice — New York, New York, United States (enrolling)
- UCSF Helen Diller Family Comprehensive Cancer Center — San Francisco, California, United States (enrolling)
- Moffitt Cancer Center, Richard M. Shulze Family Foundation Outpatient Center — Tampa, Florida, United States (enrolling)
- Moffitt Cancer Center — Tampa, Florida, United States (enrolling)
- MSK Commack. — Commack, New York, United States (enrolling)
- Laura & Isaac Perlmutter Cancer Center at NYU Langone Health — New York, New York, United States (enrolling)
- Massachusetts General Hospital — Boston, Massachusetts, United States (enrolling)
- The Angeles Clinic and Research Institue, A Cedars-Sinai Affiliate (Emergency Back-up only) — Santa Monica, California, United States (enrolling)
- Brigham and Women's Hospital — Boston, Massachusetts, United States (enrolling)
- Dana-Farber Cancer Institute — Boston, Massachusetts, United States (enrolling)
- Mass General Waltham — Waltham, Massachusetts, United States (enrolling)
- Brigitte Harris Cancer Pavilion — Detroit, Michigan, United States (enrolling)
- Henry Ford Hospital — Detroit, Michigan, United States (enrolling)
- Moffitt McKinley Hospital — Tampa, Florida, United States (enrolling)
- UCSF Helen Diller Medical Center at Parnassus Heights — San Francisco, California, United States (enrolling)
- UCSF Medical Center, Investigational Pharmacy — San Francisco, California, United States (enrolling)
- Laura & Isaac Perlmutter Cancer Center - NYU ACC — New York, New York, United States (enrolling)
- MSK Basking Ridge. — Basking Ridge, New Jersey, United States (enrolling)
- MSK Monmouth. — Middletown, New Jersey, United States (enrolling)
- MSK Bergen. — Montvale, New Jersey, United States (enrolling)
- Ophthalmic Consultants of Boston Inc (OCB) — Boston, Massachusetts, United States (enrolling)
- Columbia University Irving Medical Center — New York, New York, United States (enrolling)
Full record on ClinicalTrials.gov
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