Centralized Prescribing for Statins
Running, not enrolling · Not applicable
Conditions studied: Hyperlipidemias
In brief
This pilot study consists of a pair of pragmatic clinical trials that will evaluate two separate methods for optimizing referral of eligible patients to a centralized pharmacy service for statin management: 1) A stepped wedge clinical trial, with randomization at the level of the provider, evaluating a visit-based nudge for referral to pharmacy services versus usual care; 2) A cluster randomized trial, with randomization at the level of the practice, evaluating a non-visit based nudge for referral to pharmacy services versus usual care.
Key facts
- Study ID
- NCT05537064
- Run by
- University of Pennsylvania
- People needed
- 1950
- Starts
- 2022-11-02
- Expected to finish
- 2027-02-01
- Last updated by the study team
- 2026-04-06
Who can join
Age: 21 and older, up to 75. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Primary Care Providers with at least 10 patients among their entire panel who meet the following criteria:
- Have a LGH PCP, AND
- 21-75 years old, AND
- An indication for high- or moderate-intensity statin, AND
- Pooled cohort risk equation 10-year ASCVD risk greater than 10%, OR
- diabetes mellitus, OR
- very high LDL-C > 190 mg/dL, OR
- familial hyperlipidemia, OR
- established ASCVD,
- Not currently on statin therapy, OR on low dose-statin therapy
You may not qualify if…
- Have an allergy to statins
- Severe renal insufficiency defined as glomerular filtration rate (GFR) less than 30 mL/min or on dialysis
- Adverse reaction to statins including statin-related a) myopathy; b) Rhabdomyolysis; c) hepatitis
- Pregnant
- Currently breastfeeding
- On hospice or at the end-of-life
- On a PCSK9 Inhibitor medication
- Physicians (and their respective patients) will be excluded if they have less than 10 patients among their entire panel that are eligible for a statin medication.
Where it is running
- Lancaster General Hospital — Lancaster, Pennsylvania, United States
Full record on ClinicalTrials.gov
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