ctDNA Methylation Application in Postoperative Relapse and Adjuvant Chemotherapy Efficacy Evaluation
Recruiting now
Conditions studied: Cancer Colorectal
In brief
In this study, the investigators aimed to apply their previously developed multi-locus blood-based assay targeting circulating tumor DNA methylation to monitor postoperative relapse and evaluate adjuvant chemotherapy efficacy in resected stage I and stage II (without high risk) colorectal cancer after radical resection.
Key facts
- Study ID
- NCT05536089
- Run by
- Singlera Genomics Inc.
- People needed
- 2000
- Starts
- 2022-09-05
- Expected to finish
- 2028-12-01
- Last updated by the study team
- 2024-05-22
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients must have histologically confirmed stage I/II (without high risk) colorectal cancer.
- Male or female ≥ 18 years of age on the day of signing informed consent.
- Patients need to receive surgical resection, and with ctDNA positive prior to resection of colorectal cancer (CRC).
- Patients must have a performance status of ≤1 on the Eastern Cooperative Oncology Group (ECOG) Performance Scale.
- Written informed consent must be obtained from patient or patient's legal representative and ability for patient to comply with the requirements of the study.
You may not qualify if…
- Personal history of colorectal cancer, colorectal adenoma or aerodigestive tract cancer.
- Induction of neoadjuvant systemic therapy prior to resection of CRC.
- Patient is pregnant or lactating.
- Patients with a history or current evidence of any condition or abnormality that might confound the results of the study, interfere with the patient's participation for the full duration of the study, or is not in the best interest of the patient to participate, in the opinion of the Investigator.
- Inadequate tumor material (either quality and quantity) to support circulating tumor DNA (ctDNA) analysis.
Where it is running
- Second Affiliated Hospital — Hangzhou, Zhejiang, China (enrolling)
Full record on ClinicalTrials.gov
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