Cognition and Imaging With Tigertriever

Recruiting now

Conditions studied: Stroke

In brief

The objective of the COGNITIVE Study is to evaluate whether successful reperfusion with Tigertriever is associated with cognitive benefit.

Key facts

Study ID

NCT05531461

Run by

Rapid Medical

People needed

424

Starts

2024-10-28

Expected to finish

2026-11-01

Last updated by the study team

2025-05-16

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients admitted with large vessel occlusion (LVO) and treated with the Tigertriever, as indicated per the approved IFU.
• Tigertriever was used as the first line treatment in the target vessel.
• A signed informed consent.
• Age 18-75 years (inclusive).
• No known significant pre-stroke disability (pre-stroke mRS 0 or 1).

You may not qualify if…

• Use of any other IA recanalization device prior to the Tigertriever in the target vessel, including aspiration catheter.
• Evidence of acute brain hemorrhage on CT and/or MRI at admission.
• Prior hemorrhage, stroke, thrombolysis, and/or endovascular therapy in the last 3 months.
• Probable cerebral amyloid angiopathy.
• Pre-stroke diagnosed dementia and/or prescribed cholinesterase inhibitors.
• Pre-stroke diagnosed and/or currently treated major depression.
• Pre-stroke learning or intellectual disability.
• Anticipated inability to obtain 6-month follow-up assessments.

Where it is running

• University of California — Los Angeles, California, United States (enrolling)
• Corewell Health Research Institute — Grand Rapids, Michigan, United States (enrolling)
• Westchester Medical Center — New York, New York, United States (enrolling)

Full record on ClinicalTrials.gov

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