Transpulmonary Pressure Guided Mechanical Ventilation Weaning in Obesity
Stopped early · Not applicable
Conditions studied: Respiratory Failure, Obesity
In brief
This study will look at whether accounting for the amount of pressure generated by the chest wall and abdomen in a obese patient, using a measurement called transpulmonary pressure, can help shorten the amount of time patients spend on the ventilator. By decreasing the amount of time patients spend on the ventilator, they are less likely to develop complications such as infections, weakness or more procedures.
Key facts
- Study ID
- NCT05530434
- Run by
- University of Mississippi Medical Center
- People needed
- 4
- Starts
- 2022-04-11
- Expected to finish
- 2026-04-14
- Last updated by the study team
- 2026-05-14
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- on invasive mechanical ventilation for respiratory failure for < 48 hours
- obese class II or higher (BMI greater than or equal to 35.0 kg/m2)
You may not qualify if…
- contraindications to esophageal balloon catheter placement including esophageal, nasofacial, gastrointestinal abnormalities and platelets <10,000/microliter
- known pleural disease such as persistent pneumothorax, pleural effusion, or pleurodesis
- neuromuscular disease
- requires chronic mechanical ventilation prior to enrollment
- severe neurologic injury
- known difficult airway
- life expectance is less than 48 hours
Where it is running
- University of Mississippi Medical Center — Jackson, Mississippi, United States
Full record on ClinicalTrials.gov
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