Community-based Brain Health Program to Address Dementia Risk

Completed · Not applicable

Conditions studied: Dementia, Alzheimer Disease

In brief

This is a validation study to evaluate the acceptability, feasibility and preliminary efficacy of the Brain Health Program, a multimodal curriculum covering dementia risk factors and evidence-based change interventions. The goal of this study is to evaluate the Brain Health Program in individuals with identified risk factors for the onset of dementia and to prepare for a large-scale efficacy trial in this population.

Key facts

Study ID

NCT05529706

Run by

Posit Science Corporation

People needed

86

Starts

2023-04-24

Expected to finish

2024-10-18

Last updated by the study team

2026-07-27

Who can join

Age: 65 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Participants who are 65 years of age or older.
• Participants who meet criteria for one or more ADRD dementia risk factors
• Family history of Alzheimer's dementia (1st degree relative)
• Genetic marker (APOE4++)
• Subjective or objective cognitive decline (neuropsychological testing; or self-reported "yes" to the following question: "In the past two years, have you experienced a decline in your memory or thinking?"
• Poorly controlled hypertension or diabetes
• Physical inactivity <150min/week per Surgeon General guidelines
• Social isolation, in which participant rarely or never gets social and emotional support when needed
• Participants who are fluent English or Spanish speakers, per self-report, to ensure reasonable neuropsychological results on key assessments.
• Participants have access to an internet accessible device (eg. laptop, desktop computer, tablet or smartphone)
• Participants are able to attend all 12 classes (once a week for 12 weeks) and make up missed classes, as needed
• Participants are able to travel to/from YMCA location, if they choose to be a part of the in-person group

You may not qualify if…

• Inability to provide informed consent
• Cognitive Abilities Screening Instrument - Short (CASI-Short) scores ≤ 25 (suggestive of cognitive impairment)
• Participants with untreated psychiatric conditions, including substance abuse/dependence disorders.
• Participants enrolled in a concurrent clinical trial involving an investigational pharmaceutical, nutraceutical, medical device, or behavioral treatment that could affect the outcome of this study. However, participation in standard treatments (e.g., occupational therapy) or use of prescribed medications (e.g., anti-depressants) is allowable.
• Participants presently attending classes or courses like this program that is focused on dementia risk and behavior management.

Where it is running

• YMCA of San Francisco — San Francisco, California, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.